Pasukan penyelidik dari Universiti Mie di Jepun telah mendapati bahawa embrio ikan zebra awal (embrio beberapa jam selepas persenyawaan) boleh disinari dengan selamat dengan 278 nm UVC.
UVC-LED sekitar 260nm digunakan untuk pensterilan kerana ia mendorong dan menyahaktifkan kerosakan DNA daripada bakteria dan virus. Kebanyakan penyelidikan semasa memfokuskan pada kesan UVC dengan panjang gelombang di bawah 240nm (207nm, 222nm, 233nm) untuk membunuh coronavirus baharu. Walau bagaimanapun, terdapat beberapa kajian mengenai ketoksikan, keselamatan, dan tindak balas organisma kepada penyinaran UVC sekitar 280 nm.
Therefore, this time, a total of 16 irradiation doses were set in the range of 0.5 to 60 mJ/cm² using the irradiation device developed by the research group to irradiate 278 nm UVC, and zebrafish embryos were directly irradiated.
After 3 days of irradiation, the researchers evaluated the survival rate, hatching rate, heart rate, deformity rate, etc. of zebrafish embryos. The results found that all embryos remained alive under the irradiation dose below 4.5mJ/cm². However, when the dose reached 7.5 mJ/cm², the deformity rate significantly increased to 82 percent , and the survival rate decreased to 37 percent . Embryo death was observed if the dose was increased to 10 mJ/cm² and above.
Based on the above experimental results, the researchers determined that there is a biological defense system inside the zebrafish embryo, which can resist the damage caused by UVC irradiation to the greatest extent, and the limit dose that can resist UVC irradiation is 4.5 mJ/cm².
The researchers believe that the biological defense mechanism of zebrafish against UVC-induced DNA damage is that after zebrafish embryos are treated with UVC at a dose of 4.5 mJ/cm², the p53 signaling pathway in cells is immediately and urgently activated. Arrest, DNA repair, cell division/proliferation and damaged cell death in rapid response to stress. In addition, after 3 days of recovery, p53 variability was attenuated and instead activated the STAT signaling pathway, which continued to repair damaged DNA.
Hasil penyelidikan subjek ini menyediakan asas saintifik untuk keselamatan UVC-LED yang digunakan pada tubuh manusia. Pada masa yang sama, pasukan penyelidik mendapati bahawa UVC sesuai untuk pembasmian kuman bakteria dan virus termasuk coronavirus, serta pembasmian kuman dalam akuakultur.
"Experts say UV" believes that: at the application level, the sterilization experience of UVC-LED is difficult to intuitively perceive, and consumers will have concerns about safety when using it. brings confidence.
Teknologi LED GMKJ terlibat secara mendalam dalam sumber cahaya yang sihat dan pintar, menyediakan pasaran dengan rangkaian penuh UVA UVB UVC LED, produk dan penyelesaian VCSEL LED IR inframerah serta mempunyai ratusan rakan kongsi-berkualiti tinggi di dalam dan luar negara. pasaran untuk bersama-sama mempromosikan penggunaan teknologi ringan untuk mencipta kehidupan yang sihat dan pintar. sebab.